Hehne H J, Oelze C, Riede U N
Z Orthop Ihre Grenzgeb. 1981 Oct;119(5):449-54. doi: 10.1055/s-2008-1053316.
We analysed the tibial cartilage of 5 juvenile and 10 adult non-degenerative knees for morphometric criteria. Determination of cellular and nuclear total volume per unit cartilage volume,, number of cells and nuclei per unit cartilage volumen and cellular and nuclear single volumen of chondrocytes in the superficial and basal cartilage layer was done in relation to their being covered by meniscus. We found cells and nuclei and their total volumen in the superficial layer constantly smaller, number of chondrocytes and nuclei constantly higher than in the basal layer. This was clearly seen in the meniscus-covered part of cartilage, less marked in the central non-covered part. In adults the central cells are superficially hypertrophic and gain few individual and total volume in the basal layer. These superficial central cells are on a high level of metabolism, synthesising much intercellular substance, but they prostrate in basal direction. The aging chondrocyte is maximal adapted to the strain and uncapable to react to further load.
我们分析了5个青少年和10个成人非退行性膝关节的胫骨软骨，以确定形态学标准。测定了表层和基底层软骨细胞的单位软骨体积的细胞和细胞核总体积、单位软骨体积的细胞和细胞核数量以及细胞和细胞核的单个体积，并分析了它们与半月板覆盖情况的关系。我们发现表层的细胞、细胞核及其总体积始终较小，软骨细胞和细胞核数量始终高于基底层。这在半月板覆盖的软骨部分很明显，在中央未覆盖部分则不太明显。在成年人中，中央细胞在表层肥大，在基底层的个体体积和总体积增加较少。这些表层中央细胞处于高代谢水平，合成大量细胞间物质，但它们向基底层方向倒伏。老化的软骨细胞对应变的适应性最强，无法对进一步的负荷做出反应。
