Zaĭtseva K K, Skorik V I, Shliapnikova S A
Biull Eksp Biol Med. 1981 Dec;92(12):653-6.
Experiments on 8 dogs with acute respiratory hypoxia that lasted 1.5-2 hours were made to study ultrastructure of the aerohematic barrier, lung surface activity and the composition of individual phospholipid fractions in bronchoalveolar washings. The studies were performed with the use of histological, electron microscopy, physical and biochemical methods. The dogs with acute hypoxia manifested the impairment of the aerohematic barrier ultrastructure, edema of the interalveolar septa, a 5-fold decrease in the surface lung activity, a significant lowering of the content of phosphatidylcholine (the main component of lung surfactant) in the bronchoalveolar washings, as well as a concurrent 2-fold increase in the content of lysophosphatidylcholine with low surface active properties. Possible causes of alterations in the aerohematic barrier and lung surfactant in acute hypoxia are discussed.
对8只患有持续1.5 - 2小时急性呼吸性缺氧的狗进行了实验，以研究气血屏障的超微结构、肺表面活性以及支气管肺泡灌洗中各磷脂组分的组成。采用组织学、电子显微镜、物理和生化方法进行研究。急性缺氧的狗表现出气 - 血屏障超微结构受损、肺泡间隔水肿、肺表面活性降低5倍、支气管肺泡灌洗中磷脂酰胆碱（肺表面活性物质的主要成分）含量显著降低，同时具有低表面活性的溶血磷脂酰胆碱含量增加2倍。讨论了急性缺氧时气 - 血屏障和肺表面活性物质改变的可能原因。
