Michailov M C, Hohlbrugger G
Urol Int. 1981;36(4):225-34. doi: 10.1159/000280765.
Urol--a compound of extracts from rad. Rubiae, sem. Ammeos visnagae, herb. Virgaureae, rad. Taraxaci and aescin - induced changes in the mechanical activity (isotonic registration) of guinea pig and rat ureter, detrusor and vas deferens preparations when applied at concentrations of 10 ng to 100 microgram/ml. Low concentrations (10 ng to 1 microgram/ml) had an inhibitory effect on the spontaneous mechanical phasic activity in about half of the ureter preparations and a stimulatory effect on the remaining preparations; higher concentrations (1-100 microgram/ml) had a predominantly inhibitory effect. Urol acted similarly on detrusor preparations; it inhibited (up to 30% at 10 mg/ml) or stimulated the contractile responses after nerve stimulation (10 Hz, 0.3 ms, 3 s); it had a purely inhibitory effect on the contractions of vas deferens after nerve stimulation and had an inhibitory effect on X-ray-induced contractions in detrusor muscle preparations. The effects of Urol were observed at therapeutically relevant concentrations (about 1-10 microgram/ml). The nonuniform effects of Urol on urinary tract preparations suggest a reason for the differences in therapeutic response observed in clinical trials.
优罗（Urol）——一种由茜草提取物、阿米索司维纳格（Ammi visnaga）种子、黄花耆（Virgaurea）全草、蒲公英根提取物和七叶皂苷组成的化合物，在浓度为10纳克至100微克/毫升时，可引起豚鼠和大鼠输尿管、逼尿肌及输精管标本机械活动（等张记录）的变化。低浓度（10纳克至1微克/毫升）对约半数输尿管标本的自发机械性节律活动有抑制作用，对其余标本则有刺激作用；高浓度（1至100微克/毫升）主要起抑制作用。优罗对逼尿肌标本的作用类似；它抑制（在10毫克/毫升时可达30%）或刺激神经刺激（10赫兹、0.3毫秒、3秒）后的收缩反应；对神经刺激后输精管的收缩有纯粹的抑制作用，对X射线诱导的逼尿肌标本收缩有抑制作用。在治疗相关浓度（约1至10微克/毫升）下观察到了优罗的作用。优罗对尿路标本的作用不一致，这提示了在临床试验中观察到的治疗反应差异的原因。
