Hughson M D, Harley R A, Henninger G R
Arch Pathol Lab Med. 1982 Feb;106(2):71-4.
Angioblastic-appearing nodules of small arteries of heart, pancreas, and kidneys were found during microscopic study of autopsy specimens form subjects with hypertension that had responded poorly to treatment. These vascular lesions were noted in three of 15 subjects studied; they were associated with a proliferative arteriolosclerosis that was most severe in the kidney and the pancreas, but was occasionally found in the arterioles of the heart. Two of these three subjects had received treatment with dialysis; one had not. The nodules originated concentrically along a segment of small artery and consisted of a mass of mesenchymal cells and capillary-sized blood channels. There were fragmentation and focal loss of the internal elastic lamina at their points of origin, and vessel-wall necrosis in an occasional lesion. Many of these nodules appeared identical to plexiform lesions of the lung and to cellular types of Charcot-Bouchard aneurysms of the CNS.
在对治疗反应不佳的高血压患者尸检标本进行显微镜检查时，发现心脏、胰腺和肾脏的小动脉出现血管母细胞样结节。在研究的15名受试者中，有3名发现了这些血管病变；它们与增生性小动脉硬化有关，这种病变在肾脏和胰腺中最为严重，但偶尔也见于心脏的小动脉。这三名受试者中有两名接受了透析治疗；一名未接受透析治疗。这些结节沿小动脉节段呈同心状起源，由一团间充质细胞和毛细血管大小的血道组成。在其起源部位，内弹性膜有断裂和局灶性缺失，偶尔可见病变处的血管壁坏死。许多这些结节与肺部的丛状病变以及中枢神经系统的细胞型夏科-布夏尔动脉瘤相似。
