Rolland A, Bioulac P, Saric J, Balabaud C
Arch Pathol Lab Med. 1982 Mar;106(3):150-2.
We incidentally observed that rats with portacaval shunts (PCS) had patchy hepatic necrosis after bile-duct ligation (BDL). Rats with two weeks of PCS underwent BDL, then were killed after 0,5 or 20 hours, or two or four days; rats undergoing sham PCS were used as controls. Patchy hepatic necrosis distributed at random within the acinus was mainly lytic after five and 20 hours, then displayed inflammatory features after two days. The inflammation tends to disappear by four days, with a differentiation of new hepatocytes into neo-bile ducts. These necrotic areas were 60 times more severe after five hours, and 20 times more severe after 20 hours in rats undergoing PCS than in those undergoing sham PCS. In the former group, necrosis after five hours represented 1.92% of the total area examined. Histological characteristics and the high incidence with PCA suggest that necroses have vascular origin.
我们偶然观察到，患有门腔分流术（PCS）的大鼠在胆管结扎（BDL）后出现了散在性肝坏死。患有两周PCS的大鼠接受BDL，然后在0、5或20小时，或两天或四天后处死；接受假PCS的大鼠用作对照。散在性肝坏死随机分布于腺泡内，在5小时和20小时时主要为溶解性坏死，两天后表现出炎症特征。炎症在四天时趋于消失，同时有新的肝细胞分化为新的胆管。与接受假PCS的大鼠相比，接受PCS的大鼠在5小时时这些坏死区域严重程度高60倍，在20小时时高20倍。在前一组中，5小时时的坏死占检查总面积的1.92%。组织学特征以及PCA的高发生率表明坏死起源于血管。
