特定配方饮食在预防大鼠应激性胃黏膜损伤中的作用

The role of a defined formula diet in the prevention of stress-induced gastric mucosal injury in the rat.

作者信息

Mabogunje O A, Andrassy R J, Isaacs H, Mahour G H

出版信息

J Pediatr Surg. 1981 Dec;16(6):1036-9. doi: 10.1016/s0022-3468(81)80871-8.

Abstract

The role of a defined formula diet, Vivonex HN, in the prevention of gastric mucosal injury was evaluated in the cold, restrained rat model. The mean grade of gastric bleeding and mean number of gastric lesions were 3.95 and 7.35 +/- 1.02, respectively, in the stressed, unprotected control group. In four random groups of rats given Vivonex HN, Maalox, Cimetidine (20 mg/kg) and Cimetidine (60 mg/kg) prior to stress, the mean grade of gastric bleeding was 0; 1.55; 2.33; 1.75; and the mean number of gastric lesions was 0; 1.2 +/0 0.31; 2.83 +/0 0.82; 2.2 +/- 0.65, respectively. The differences were statistically significant. Our experiments show that Vivonex HN was more effective than Maalox or Cimetidine in high dose in preventing gastric bleeding and gastric mucosal lesions in the cold, restrained rat. Cimetidine in a standard dose was the least protective. Clinical trials are needed to establish the role of Vivonex HN in the prevention of stress ulcers in patients at risk.

摘要

在冷束缚大鼠模型中评估了一种特定配方饮食（Vivonex HN）在预防胃黏膜损伤方面的作用。在应激、未受保护的对照组中，胃出血的平均等级和胃损伤的平均数量分别为3.95和7.35±1.02。在应激前给予Vivonex HN、氢氧化铝镁、西咪替丁（20mg/kg）和西咪替丁（60mg/kg）的四组随机大鼠中，胃出血的平均等级分别为0；1.55；2.33；1.75；胃损伤的平均数量分别为0；1.2±0.31；2.83±0.82；2.2±0.65。差异具有统计学意义。我们的实验表明，在预防冷束缚大鼠的胃出血和胃黏膜损伤方面，Vivonex HN比氢氧化铝镁或高剂量西咪替丁更有效。标准剂量的西咪替丁保护作用最小。需要进行临床试验以确定Vivonex HN在预防高危患者应激性溃疡中的作用。