具有标记酰基的1,2 - 二棕榈酰 - sn - 甘油 - 3 - 磷酸胆碱的合成。
Synthesis of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine with labeled acyl groups.
作者信息
Brimble P D, Choy P C
出版信息
Prep Biochem. 1981;11(5):525-33. doi: 10.1080/00327488108065540.
PMID:6896091
Abstract
A facile procedure for the small scale chemical synthesis of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPL) is reported. Under optimal conditions, 36% of the sn-glycero-3-phosphocholine was converted to DPL. This procedure is suitable for small scale preparation of DPL with very high specific radioactivity from labeled palmitic acid. Furthermore, the labeled DPL obtained will serve as precursor for the chemical or enzymatic synthesis of other labeled phospholipids.
摘要
报道了一种用于小规模化学合成1,2 - 二棕榈酰 - sn - 甘油 - 3 - 磷酸胆碱（DPL）的简便方法。在最佳条件下，36%的sn - 甘油 - 3 - 磷酸胆碱转化为DPL。该方法适用于从标记的棕榈酸小规模制备具有非常高比放射性的DPL。此外，所获得的标记DPL将作为其他标记磷脂化学或酶促合成的前体。
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