Roninson I B, Ingram V M
Cell. 1982 Mar;28(3):515-21. doi: 10.1016/0092-8674(82)90206-9.
We have determined the cDNA sequence of the chicken embryonic beta-like epsilon-globin gene. Comparison with the sequences of the chicken rho-globin and beta-globin genes reveals the presence of two regions that are identical or nearly identical in epsilon and rho. The first contains the 5' untranslated sequence and exon 1, while the second region includes the second half of exon 2. Outside these regions rho and epsilon are less homologous to each other than to the adult beta-globin gene. The embryonic rho and epsilon genes are located at opposite ends of the beta-globin-gene cluster, not contiguously as are all other known pairs of simultaneously expressed globin genes. We suggest a role for gene conversion in the synchronization of expression of two highly diverged genes.
我们已经确定了鸡胚胎β样ε-珠蛋白基因的cDNA序列。与鸡ρ-珠蛋白基因和β-珠蛋白基因的序列比较显示，在ε和ρ中有两个区域是相同或几乎相同的。第一个区域包含5'非翻译序列和外显子1，而第二个区域包括外显子2的后半部分。在这些区域之外，ρ和ε之间的同源性低于它们与成年β-珠蛋白基因的同源性。胚胎期的ρ和ε基因位于β-珠蛋白基因簇的两端，不像所有其他已知的同时表达的珠蛋白基因对那样相邻。我们认为基因转换在两个高度分化的基因表达同步中起作用。
