Popow C, Rameis H, Simbruner G, Weninger M, Hitzenberger G
Padiatr Padol. 1982;17(2):513-20.
We studied the serum concentrations of gentamicin by radio-immuno-assay in 22 sick prematures (birth weight 1713 +/- 469 g, prenatal age 33 +/- 3 weeks, postnatal age 12 +/- 9 days) receiving 2.5 mg/kg bid. Bactericidal concentrations were present in 91% but only 50% had normal serum concentrations and gentamicin half-lives. Gentamicin half-life decreased significantly (p less than 0.01) with postnatal age but there was no statistically significant correlation between gentamicin serum concentration and gestational age or birth weight. We therefore recommend 1. gentamicin serum concentrations to be monitored routinely in therapy of prematures especially in the first week of life, 2. to expand the dosage interval up to 18 hours (which is about the threefold half-life) in prematures during the first week of life.
我们采用放射免疫分析法研究了22例患病早产儿（出生体重1713±469克，胎龄33±3周，出生后年龄12±9天）接受2.5毫克/千克、每日两次给药时庆大霉素的血清浓度。91%的患儿血清中有杀菌浓度，但只有50%的患儿血清浓度和庆大霉素半衰期正常。庆大霉素半衰期随出生后年龄显著降低（p<0.01），但庆大霉素血清浓度与胎龄或出生体重之间无统计学显著相关性。因此，我们建议：1. 在早产儿治疗中，尤其是在出生后的第一周，应常规监测庆大霉素血清浓度；2. 在出生后的第一周，将早产儿的给药间隔延长至18小时（约为半衰期的三倍）。
