Tabel H, Losos G J, Maxie M G, Minder C E
Tropenmed Parasitol. 1981 Sep;32(3):149-53.
Twenty-five steers were infected with T. vivax (EATRO 1721), 25 steers with T. congolense (EATRO 1800) and 25 steers kept as controls. Serum levels of immunoglobulins (IgG1, IgG2, IgM), natural antibodies to erythrocytes of chicken and sheep, and complement-fixing antibodies to T. vivax were measured. A significant decrease of serum IgM and natural antibodies to chicken erythrocytes occurred in the T. vivax group at day 9, i.e. at the decline of the first parasitemic wave. This was followed by a transient moderate increase of IgM accompanied by a transient decrease of IgG2. The T. congolense group had moderate decreases (less than 30%) of the mean IgG1 levels and moderate increases (less than or equal to 50%) of the mean IgG2, levels. It was concluded that there was little evidence for polyclonal activation of lymphocytes and that the decreased IgG1 levels in the T. congolense group might have been a reflection of immunosuppression. The complement-fixation test proved to be a sensitive tool for monitoring the antibody response to T. vivax.
25头公牛感染了活泼锥虫（伊巴丹锥虫EATRO 1721株），25头公牛感染了刚果锥虫（伊巴丹锥虫EATRO 1800株），另有25头公牛作为对照。检测了血清免疫球蛋白（IgG1、IgG2、IgM）水平、针对鸡和绵羊红细胞的天然抗体以及针对活泼锥虫的补体结合抗体。在第9天，活泼锥虫组血清IgM和针对鸡红细胞的天然抗体显著下降，即处于第一个虫血症波峰下降阶段。随后IgM短暂适度升高，同时IgG2短暂下降。刚果锥虫组平均IgG1水平适度下降（小于30%），平均IgG2水平适度升高（小于或等于50%）。得出的结论是，几乎没有证据表明淋巴细胞存在多克隆激活，刚果锥虫组IgG1水平下降可能反映了免疫抑制。补体结合试验被证明是监测针对活泼锥虫抗体反应的敏感工具。
