Nielsen K, Sheppard J, Holmes W, Tizard I
Immunology. 1978 Nov;35(5):817-26.
In three calves experimentally infected with Trypanosoma congolense the amounts of IgG1 and IgG2 were little changed and similar to those of normal animals. IgM increased in amount early in the infection and the amount of the increase appeared related to the parasite burden. The amounts of IgA and IgE were both much decreased and this also appeared related to the numbers of parasites in the blood. There was a decrease in the amounts of total haemolytic complement and complement components C1, C1q and C3 in the infected calves. Furthermore the amounts of properdin fluctuated with the cyclical changes in numbers of T. congolense parasites in the individual calves. No significant change in the amount of C8 was observed. It is considered that activation of both the alternative and the classical complement pathways occurs in trypanosome infected animals but that neither pathway goes to its terminal stages.
在三只实验感染刚果锥虫的小牛中，IgG1和IgG2的量变化不大，与正常动物的量相似。感染初期IgM量增加，增加的量似乎与寄生虫负荷有关。IgA和IgE的量均大幅下降，这似乎也与血液中的寄生虫数量有关。感染小牛的总溶血补体以及补体成分C1、C1q和C3的量均减少。此外，备解素的量随个体小牛中刚果锥虫寄生虫数量的周期性变化而波动。未观察到C8量的显著变化。据认为，在锥虫感染的动物中，替代补体途径和经典补体途径均被激活，但两条途径均未进入其终末阶段。
