Sherban S D, Danko M I, Monastyrskaia B D, Morgun V Ia, Bagleĭ E A
Ukr Biokhim Zh (1978). 1982 May-Jun;54(3):298-306.
The paper is concerned with composition of neutral lipids and phospholipids, the regularity of lipid bilayer and structural reorganization of plasma membranes, and membranes of smooth and rough cell reticulum of thymus and Pliss lymphosarcoma are studied at linear and stationary growth phase. No qualitative differences are found in the fatty-acid composition of lipid membranes in normal and tumour cells. In plasma membranes of phospholipids and in membranes of smooth reticulum of tumour cells the unsaturated lipid component increases in the process of growth, the cholesterin/phospholipids ratio decreases, fluidity of the lipid bilayer diminishes and structural heterogeneity of these membranes rises while in membranes of rough reticulum the saturation of lipids increases, but the cholesterin/phospholipids ratio does not change. The temperatures of structural reorganization also does not change, which evidences for a less structural lability of membranes of rough reticulum as compared with other membranes.
本文关注中性脂质和磷脂的组成、脂质双层的规律以及质膜的结构重组，并对胸腺和普利斯淋巴肉瘤在线性生长阶段和平稳生长阶段的光滑内质网和粗面内质网的膜进行了研究。在正常细胞和肿瘤细胞的脂质膜脂肪酸组成中未发现定性差异。在肿瘤细胞质膜的磷脂以及光滑内质网的膜中，不饱和脂质成分在生长过程中增加，胆固醇/磷脂比值降低，脂质双层的流动性减小，这些膜的结构异质性增加；而在粗面内质网的膜中，脂质饱和度增加，但胆固醇/磷脂比值不变。结构重组的温度也没有变化，这表明与其他膜相比，粗面内质网的膜结构稳定性较低。
