Yoshida M, Egawa K, Kasai N
Toxicol Lett. 1982 Jul;12(2-3):185-90. doi: 10.1016/0378-4274(82)90184-9.
Effect of Salmonella minnesota R595 endotoxin (R595 GL) and its chemical degradation products on hepatic cytochrome P-450, delta-aminolevulinic acid (ALA) synthetase and heme oxygenase activity in mice was examined. The levels of cytochrome P-450 and ALA synthetase activity were significantly decreased following the administration of R595 GL, whereas heme oxygenase activity was markedly increased. The effects of endotoxin were dose-dependent for the range of about 1 to 2 micrograms per mouse. The result of a comparative study using R595 GL and its degradation products suggested that intact lipid A moiety plays an important rôle in the activity of endotoxin. In addition, it was found that the depressant effect of endotoxin on the hepatic mixed-function oxidase system in mice was abrogated by treatment with cortisone.
研究了明尼苏达沙门氏菌R595内毒素（R595 GL）及其化学降解产物对小鼠肝细胞色素P - 450、δ-氨基乙酰丙酸（ALA）合成酶和血红素加氧酶活性的影响。给予R595 GL后，细胞色素P - 450水平和ALA合成酶活性显著降低，而血红素加氧酶活性明显增加。内毒素的作用在每只小鼠约1至2微克的剂量范围内呈剂量依赖性。使用R595 GL及其降解产物的比较研究结果表明，完整的脂多糖A部分在内毒素活性中起重要作用。此外，还发现用可的松治疗可消除内毒素对小鼠肝脏混合功能氧化酶系统的抑制作用。
