Bergan T, Fotland M H, Sund R B
Acta Pharmacol Toxicol (Copenh). 1982 Aug;51(2):165-72. doi: 10.1111/j.1600-0773.1982.tb01009.x.
The ability of the laxative diphenols desacetylbisacodyl, oxyphenisatin, and phenolphthalein to inhibit growth and cause leakage of potassium ion from microbial cells in vitro was studied with 25 aerobic and 25 anaerobic bacterial strains. None of the aerobes, but some of the anaerobes showed growth inhibition. Potassium release assayed by flame photometry was observed in strains which showed growth inhibition, but also in other strains including anaerobes and aerobes. The highest antibacterial activity among the diphenols was observed with phenolphthalein and the least with desacetylbisacodyl; this relationship as noted for both growth inhibition and potassium release. Enzymatic hydrolysis of picosulphate to the free diphenol desacetylbisacodyl carried out by three strains of anaerobic bacteria was indicated by high pressure liquid chromatography.
用25株需氧菌和25株厌氧菌研究了缓泻药二酚类药物去乙酰双醋酚丁、奥昔酚酞和酚酞在体外抑制微生物细胞生长及导致钾离子泄漏的能力。所有需氧菌均未表现出生长抑制，但部分厌氧菌有生长抑制现象。通过火焰光度法测定钾释放，发现不仅在表现出生长抑制的菌株中观察到钾释放，在包括厌氧菌和需氧菌的其他菌株中也观察到了钾释放。二酚类药物中酚酞的抗菌活性最高，去乙酰双醋酚丁的抗菌活性最低；生长抑制和钾释放均呈现这种关系。高压液相色谱法表明，三株厌氧菌可将匹可硫酸钠酶解为游离二酚类药物去乙酰双醋酚丁。
