Shibata S, Miura K
Nephron. 1982;31(2):170-6. doi: 10.1159/000182638.
Glomerular basement membrane (GBM) damage has been considered as the only source of the nephritogenic glycoprotein excreted in urine. However, in the course of our investigation on the glycoprotein or glycopeptide isolated from the urine of a disease group seldom affected with GBM damage, it appeared that a second source of the nephritogenic glycoprotein excreted in the urine is in blood plasma; that is, in Zn-alpha2-glycoprotein. Zn-alpha2-glycoprotein is the only plasma protein which has a common determinant with nephritogenic urinary glycoprotein or glycopeptides. It was proposed that plasma Zn-alpha2-glycoprotein may play the role of a carrier protein of the nephritogenic renal glycoprotein.
肾小球基底膜（GBM）损伤一直被认为是尿液中排出的致肾炎糖蛋白的唯一来源。然而，在我们对从很少受GBM损伤的疾病组尿液中分离出的糖蛋白或糖肽进行研究的过程中，发现尿液中排出的致肾炎糖蛋白的第二个来源是血浆；也就是说，存在于锌-α2-糖蛋白中。锌-α2-糖蛋白是唯一一种与致肾炎尿糖蛋白或糖肽具有共同决定簇的血浆蛋白。有人提出，血浆锌-α2-糖蛋白可能起到致肾炎肾糖蛋白载体蛋白的作用。
