Smith P S, McClure J
Arch Pathol Lab Med. 1982 Oct;106(10):503-6.
An endobronchial papillary tumor in a 75-year-old reformed cigarette smoker exhibited the light microscopic features of a transitional cell neoplasm. The constituent cells showed cytologic features of malignancy; in addition, there were microfoci of mucosal invasion. Electron microscopy showed tonofilaments and numerous desmosomes. There were no ultrastructural features similar to those seen in tumors of urothelial origin, and the similarity with the latter was only at the light microscopic level, the tumor being a variant of a squamous carcinoma. Previous descriptions of so-called transitional cell neoplasms of the lower bronchial tree included a cytologically benign lesion an one showing carcinoma in situ. The present case indicated that the spectrum of these neoplasms includes lesions that show microinvasion. Therefore, exophytic papillary endobronchial tumors should be distinguished as a group of distinct variants of squamous carcinoma.
一名75岁已戒烟的吸烟者患有支气管内乳头状肿瘤，其光镜下表现为移行细胞肿瘤的特征。组成细胞显示出恶性的细胞学特征；此外，存在黏膜侵犯的微小病灶。电子显微镜检查显示有张力丝和大量桥粒。不存在与尿路上皮起源肿瘤所见相似的超微结构特征，且与后者的相似性仅在光镜水平，该肿瘤为鳞状细胞癌的一种变体。先前对下支气管树所谓移行细胞肿瘤的描述包括一种细胞学上良性的病变以及一种原位癌表现。本病例表明这些肿瘤的谱系包括显示微小浸润的病变。因此，外生性支气管内乳头状肿瘤应被区分为鳞状细胞癌的一组独特变体。
