Eloranta T O, Tuomi K, Raina A M
Biochem J. 1982 Jun 15;204(3):803-7. doi: 10.1042/bj2040803.
5'-Methylthioadenosine was taken up and immediately metabolized further by cultured baby-hamster kidney cells during the exponential phase of growth. The adenine moiety supplied the purine-nucleotide pool via the salvage pathway and was efficiently incorporated into nucleic acids. Catabolites of methylthioadenosine excreted by the cells included adenine, purinic compounds and metabolites of the ribose portion. 5'-Methylthiotubercidin had no significant effect on the cellular metabolism of methyl-thioadenosine, but greatly inhibited its uptake. erythro-9-(2-Hydroxy-3-nonyl)adenine had no effect on the uptake, but markedly interfered with the further utilization of methylthioadenosine after cleavage in the cells.
在生长指数期，培养的幼仓鼠肾细胞摄取了5'-甲硫腺苷并立即将其进一步代谢。腺嘌呤部分通过补救途径供应嘌呤核苷酸池，并有效地掺入核酸中。细胞分泌的甲硫腺苷分解代谢产物包括腺嘌呤、嘌呤化合物和核糖部分的代谢产物。5'-甲硫基杀结核菌素对甲硫腺苷的细胞代谢没有显著影响，但极大地抑制了其摄取。赤藓红-9-(2-羟基-3-壬基)腺嘌呤对摄取没有影响，但显著干扰了细胞中甲硫腺苷裂解后进一步的利用。
