Beaudet A L, Su T S, O'Brien W E, D'Eustachio P, Barker P E, Ruddle F H
Cell. 1982 Aug;30(1):287-93. doi: 10.1016/0092-8674(82)90034-4.
DNA sequences closely homologous to argininosuccinate synthetase are present at ten or more distinct locations in the human genome, including sites on chromosomes 6, 9 and X. Argininosuccinate synthetase thus represents one of the most widely dispersed multigene families described to date, the first instance of a multigene family associated with an enzyme of intermediary metabolism and, perhaps most striking, the first instance of a multigene family with members on both autosomes and sex chromosomes.
与精氨琥珀酸合成酶密切同源的DNA序列存在于人类基因组的十个或更多不同位置，包括6号、9号和X染色体上的位点。因此，精氨琥珀酸合成酶代表了迄今为止所描述的分布最广泛的多基因家族之一，是与中间代谢酶相关的多基因家族的首个实例，也许最引人注目的是，是一个成员同时存在于常染色体和性染色体上的多基因家族的首个实例。
