持续光照下大鼠的DSIP/DSIP-P与昼夜运动活动

DSIP/DSIP-P and circadian motor activity of rats under continuous light.

作者信息

Graf M, Christen H, Schoenenberger G A

出版信息

Peptides. 1982 Jul-Aug;3(4):623-6. doi: 10.1016/0196-9781(82)90161-9.

Abstract

Daily intravenous injection of 30 nmol/kg DSIP (delta sleep-inducing peptide) in rats under constant illumination produced marked changes of their motor activity as compared to saline controls. Similar marked but distinctly different effects on the circadian pattern of locomotor behavior partially abolished by constant illumination were also obtained after repeated administration of 0.1 nmol/kg DSIP-P (the phosphorylated analogue of DSIP) which enhanced overall motor activity. In both instances the results additionally differed from those reported for a normal 12 hr light:dark cycle. The present results support the hypothesis that DSIP might primarily act by influencing circadian rhythmicity.

摘要

在持续光照条件下，每天给大鼠静脉注射30纳摩尔/千克的DSIP（促睡眠肽），与注射生理盐水的对照组相比，其运动活动发生了显著变化。在重复给予0.1纳摩尔/千克的DSIP-P（DSIP的磷酸化类似物）后，也观察到对在持续光照下部分被消除的昼夜运动行为模式产生了类似的显著但明显不同的影响，该类似物增强了总体运动活动。在这两种情况下，结果还与正常12小时光照：黑暗周期所报告的结果不同。目前的结果支持这样一种假说，即DSIP可能主要通过影响昼夜节律而起作用。