Pappas A A, Mullins R E, Gadsden R H
Ann Clin Lab Sci. 1982 Jul-Aug;12(4):304-7.
Assessment of the status of amniotic fluid phospholipids (qualitative and semi-quantitative) has become important in determining fetal lung maturity. In uncomplicated pregnancies, it has been documented that the ratio of lecithin to sphingomyelin (L/S ratio), with respect to pediatric gestational age, is a reliable predictor of maturity. In complicated pregnancies (e.g., toxemia, diabetes mellitus) the L/S ratio may result in erroneous clinical interpretation and premature intervention. The presence of phosphatidyl-glycerol (PG) in these cases has been acknowledge to be a significant factor indicative of fetal lung maturity. Thin-layer chromatography, which clearly elucidates the six phospholipids of amniotic fluid, is the method of choice.
评估羊水磷脂的状态（定性和半定量）在确定胎儿肺成熟度方面已变得至关重要。在无并发症的妊娠中，有记录表明，就小儿胎龄而言，卵磷脂与鞘磷脂的比例（L/S 比值）是成熟度的可靠预测指标。在复杂妊娠（如毒血症、糖尿病）中，L/S 比值可能导致错误的临床解读和过早干预。在这些情况下，磷脂酰甘油（PG）的存在被认为是表明胎儿肺成熟的一个重要因素。能清晰阐明羊水六种磷脂的薄层色谱法是首选方法。
