Midgett R J, Friedman C M, Schneider P E
Acta Vitaminol Enzymol. 1982;4(3):233-6.
In the fetal rat the specific uptake of this hormone appears in the kidney and in the mandible-tooth germ, but not by the intestine. Furthermore, uptake by the two former tissues was greatly influenced by gestational age. Localization in the mandible and tooth germ increased from approximately 50 DPM/mg wet weight of tissue on day seventeen of gestation to over 300 DPM/mg wet weight on the nineteenth day. A similar, but not as dramatic, increase occurred in the kidney. Thus, these data demonstrate: (1) the development of the specific uptake of 1,25-dihydroxy vitamin D3 in the kidney and bone with gestational age, and (2) the absence of specific receptive sites in the fetal intestine.
在胎鼠中，这种激素的特异性摄取出现在肾脏和下颌牙齿胚中，而肠道则没有。此外，前两个组织的摄取受胎龄的影响很大。下颌骨和牙齿胚中的定位从妊娠第17天的约50 DPM/毫克湿重组织增加到第19天的超过300 DPM/毫克湿重。肾脏中也出现了类似但不那么显著的增加。因此，这些数据表明：（1）随着胎龄的增加，肾脏和骨骼中1,25-二羟维生素D3特异性摄取的发育，以及（2）胎儿肠道中不存在特异性受体位点。
