Sapozhnikova M A, Barinova M V
Arkh Patol. 1982;44(8):47-55.
In the lungs of patients with acute respiratory insufficiency (ARI), perfusion-ventilation disorders are observed in the form of acute hemodynamic disturbances and progressive increased permeability at the level of the aerohematic barrier followed by the development of alveolitis and microatelectases associated with reduced surfactant production. The time of development of ARI depended on the disorders of ventilation of the pulmonary parenchyma of both local and central genesis. The involvement of the bronchial tree into the pathological process contributed to lung infection. Early pulmonary fibrosis due to fibrin organization in alveolar lumina developed as an ARI outcome. The ARI and severe changes in the lungs facilitated the development of metabolic disorders in the myocardium which in their turn aggravated the pulmonary pathology.
在急性呼吸功能不全（ARI）患者的肺部，可观察到灌注-通气障碍，表现为急性血流动力学紊乱，气血屏障水平的通透性逐渐增加，随后发展为肺泡炎和与表面活性物质产生减少相关的微小肺不张。ARI的发展时间取决于局部和中枢性起源的肺实质通气障碍。支气管树参与病理过程会导致肺部感染。肺泡腔内纤维蛋白机化导致的早期肺纤维化是ARI的一个后果。ARI以及肺部的严重变化促使心肌发生代谢紊乱，而心肌代谢紊乱反过来又加重了肺部病变。
