铬原卟啉对新生大鼠高胆红素血症的抑制作用。金属卟啉与人脾脏微粒体血红素加氧酶的相互作用。
Suppression of hyperbilirubinemia in the rat neonate by chromium-protoporphyrin. Interactions of metalloporphyrins with microsomal heme oxygenase of human spleen.
作者信息
Drummond G S, Kappas A
出版信息
J Exp Med. 1982 Dec 1;156(6):1878-83. doi: 10.1084/jem.156.6.1878.
Abstract
The synthetic metalloporphyrin, Cr-protoporphyrin, as a potent competitive inhibitor of heme oxygenase activity in rat spleen, liver, and kidney. When administered to neonatal animals in a single dose immediately after birth, Cr-protoporphyrin suppresses postnatal hyperbilirubinemia and produces a marked and sustained lowering of heme oxidation activity in liver, spleen, and kidney. The metalloporphyrin also potently inhibited the rate of heme degradation to bile pigment in human spleen.
摘要
合成金属卟啉Cr-原卟啉，是大鼠脾脏、肝脏和肾脏中血红素加氧酶活性的强效竞争性抑制剂。出生后立即给新生动物单次注射Cr-原卟啉，可抑制产后高胆红素血症，并使肝脏、脾脏和肾脏中的血红素氧化活性显著且持续降低。这种金属卟啉还能有效抑制人脾脏中血红素降解为胆色素的速率。
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Suppression of hyperbilirubinemia in the rat neonate by chromium-protoporphyrin. Interactions of metalloporphyrins with microsomal heme oxygenase of human spleen.铬原卟啉对新生大鼠高胆红素血症的抑制作用。金属卟啉与人脾脏微粒体血红素加氧酶的相互作用。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation.锡原卟啉IX预防新生儿高胆红素血症，锡原卟啉IX是血红素氧化的一种有效竞争性抑制剂。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6466-70. doi: 10.1073/pnas.78.10.6466.
3
Chemoprevention of neonatal jaundice: potency of tin-protoporphyrin in an animal model.新生儿黄疸的化学预防：锡原卟啉在动物模型中的效能
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4
Metal ion-mediated regulation of heme oxygenase induction in cultured avian liver cells.金属离子介导的培养禽肝细胞中血红素加氧酶诱导的调控
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5
Metal ion interactions in the control of haem oxygenase induction in liver and kidney.金属离子在肝脏和肾脏中血红素加氧酶诱导调控中的相互作用
Biochem J. 1980 Nov 15;192(2):637-48. doi: 10.1042/bj1920637.
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Zinc . protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat.锌原卟啉是新生大鼠血红素加氧酶活性的选择性抑制剂。
Biochim Biophys Acta. 1981 Mar 18;673(3):339-50. doi: 10.1016/0304-4165(81)90465-7.
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[Fluorimetric assay of bilirubin].
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Microsomal heme oxygenase. Characterization of the enzyme.微粒体血红素加氧酶。该酶的特性。
J Biol Chem. 1969 Dec 10;244(23):6388-94.
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The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.微粒体血红素加氧酶将血红素酶促转化为胆红素。
Proc Natl Acad Sci U S A. 1968 Oct;61(2):748-55. doi: 10.1073/pnas.61.2.748.
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