Nicar M J, Pak C Y
Miner Electrolyte Metab. 1982 Jul;8(1):44-51.
The intestinal absorption of magnesium (Mg) was estimated from the increment in urinary Mg following oral administration of 25 mmol of Mg. Fasting urinary Mg did not differ between the control group and patient groups (absorptive hypercalciuria, primary hyperparathyroidism, and hypoparathyroidism). As compared to the value in the control group, the increment in urinary Mg above the fasting value was not significantly different in absorptive hypercalciuria. However, it was significantly increased in primary hyperparathyroidism and significantly reduced in hypoparathyroidism. In control subjects, the increment in urinary Mg was much higher during a low than during a high calcium diet. The results suggest that 1,25-(OH)2-vitamin D stimulates Mg absorption, since Mg absorption was elevated in situations associated with stimulated 1,25-(OH)2-vitamin D synthesis (primary hyperparathyroidism and low calcium diet) and reduced in a condition characterized by low 1,25-(OH)2-vitamin D production (hypoparathyroidism). Moreover, the data indicate that 1,25-(OH)2-vitamin D may not be pathogenetically important in absorptive hypercalciuria, since Mg absorption was normal.
通过口服25 mmol镁后尿镁的增加量来估算肠道对镁（Mg）的吸收。对照组与患者组（吸收性高钙尿症、原发性甲状旁腺功能亢进症和甲状旁腺功能减退症）的空腹尿镁无差异。与对照组的值相比，吸收性高钙尿症患者尿镁高于空腹值的增加量无显著差异。然而，原发性甲状旁腺功能亢进症患者尿镁增加量显著升高，而甲状旁腺功能减退症患者尿镁增加量显著降低。在对照受试者中，低钙饮食期间尿镁的增加量远高于高钙饮食期间。结果表明，1,25-(OH)₂-维生素D刺激镁的吸收，因为在与1,25-(OH)₂-维生素D合成增加相关的情况下（原发性甲状旁腺功能亢进症和低钙饮食）镁的吸收增加，而在以1,25-(OH)₂-维生素D产生减少为特征的疾病（甲状旁腺功能减退症）中镁的吸收减少。此外，数据表明1,25-(OH)₂-维生素D在吸收性高钙尿症的发病机制中可能并不重要，因为镁的吸收是正常的。
