Dipartimento di Scienze Biomediche e Cliniche L. Sacco, Università di Milano, 20157 Milano, Italy.
Department of Clinical Pharmacology, University Hospital and Inserm 1107 Fundamental and Clinical Pharmacology of Pain, Medical Faculty, F-63000 Clermont-Ferrand, France.
Nutrients. 2020 Aug 31;12(9):2660. doi: 10.3390/nu12092660.
Magnesium deficiency may occur for several reasons, such as inadequate intake or increased gastrointestinal or renal loss. A large body of literature suggests a relationship between magnesium deficiency and mild and moderate tension-type headaches and migraines. A number of double-blind randomized placebo-controlled trials have shown that magnesium is efficacious in relieving headaches and have led to the recommendation of oral magnesium for headache relief in several national and international guidelines. Among several magnesium salts available to treat magnesium deficiency, magnesium pidolate may have high bioavailability and good penetration at the intracellular level. Here, we discuss the cellular and molecular effects of magnesium deficiency in the brain and the clinical evidence supporting the use of magnesium for the treatment of headaches and migraines.
镁缺乏可能有多种原因，如摄入不足或胃肠道或肾脏丢失增加。大量文献表明镁缺乏与轻度和中度紧张性头痛和偏头痛之间存在关联。许多双盲随机安慰剂对照试验表明，镁在缓解头痛方面有效，并促使一些国家和国际指南建议使用口服镁来缓解头痛。在可用于治疗镁缺乏的几种镁盐中，镁吡啶醇酸盐可能具有较高的生物利用度和良好的细胞内穿透性。在这里，我们讨论了镁缺乏对大脑的细胞和分子影响以及支持使用镁治疗头痛和偏头痛的临床证据。
