Richter K, Terhaag B
Int J Clin Pharmacol Biopharm. 1978 Aug;16(8):377-9.
Differences in the bioavailability after administration of two pure carbamazepine samples that were different in particle sizes have been found. Carbamazepine was given to each of 3 healthy male volunteers in a single oral dose of 400 mg in gelatin capsules. The other carbamazepine sample was administered after a three-week time interval. Plasma was collected during the following 96 hr. Quantitative determination of carbamazepine was performed by gas liquid chromatography. By comparing the areas under the various curves for each volunteer, the relative bioavailability of one of the carbamazepines in relation to the other one was found of approximately 70%. There were no differences in the half-life time.
已发现两种粒径不同的纯卡马西平样品给药后的生物利用度存在差异。给3名健康男性志愿者每人单次口服400mg装在明胶胶囊中的卡马西平。在三周的时间间隔后给予另一种卡马西平样品。在接下来的96小时内采集血浆。通过气液色谱法对卡马西平进行定量测定。通过比较每位志愿者的各种曲线下的面积，发现其中一种卡马西平相对于另一种卡马西平的相对生物利用度约为70%。半衰期没有差异。
