Dickhoner W H, Bradley B R, Harell G S
Invest Radiol. 1978 Jul-Aug;13(4):313-7. doi: 10.1097/00004424-197807000-00007.
An assumption inherent in the use of microsphere methodology for measuring regional blood flow is that microspheres are removed from the circulation by impacting in arterial vessels of approximately their own diameter. We investigated the in vivo relationship between the diameter of varying size microspheres and the calibre of trapping microvessels within the hamster cheek pouch. Intracardiac injection of 8-10, 15 +/- 5, 25 +/- 5 micron carbonized microspheres with diversion of the cardiac output into the bracheocephalic trunk provided direct, in vivo visualization of the impaction sites of these various size microspheres within the cheek pouch microvasculature. Fifteen micron microspheres usually impacted at the orifice or neck of small arterioles and protruded into the lumen of the parent vessel. Eight to ten micron microspheres lodged in vessels with a mean diameter of 11.5 +/- SD 3.4 micron indicating that they usually impacted primarily in terminal arterioles.
使用微球法测量局部血流量时一个内在的假设是，微球通过撞击直径与其自身大致相同的动脉血管而从循环中被清除。我们研究了不同大小微球的直径与仓鼠颊囊内捕获微血管口径之间的体内关系。经心内注射8 - 10、15±5、25±5微米的碳化微球，并将心输出量转流入头臂干，从而在体内直接观察到这些不同大小微球在颊囊微脉管系统内的撞击部位。15微米的微球通常撞击在小动脉的开口处或颈部，并突出到母血管的管腔内。8 - 10微米的微球滞留在平均直径为11.5±标准差3.4微米的血管中，这表明它们通常主要撞击在终末小动脉中。
