Hayes M A, Creighton S R, Boysen B G, Holfeld N
J Am Vet Med Assoc. 1978 Aug 1;173(3):289-5.
Two dogs that suddenly developed neurologic signs indicating a severe cervical spinal cord lesion were found at necropsy to have necrotizing myelopathy secondary to nucleus pulposus embolism. One dog had embolism of arteries and veins; in the other dog, veins alone were embolized. Each dog had early degeneration and extrusion of the C6--7 disk, from which emboli originated. In one dog, arterial emboli apparently entered inflammatory vasculature in the anulus fibrosus and were forced by extrusion back through the arterial system to the radicular artery and then to the cord. Venous embolism occurred secondarily to arterial embolism. In the other dog, venous embolism resulted from direct herniation of nucleus pulposus into the longitudinal venous sinus. A comparison of the pathogenesis of embolization in each case and a survey of other reported cases suggested that necrotizing myelopathy is a complication of early degeneration of intervertebral disks in large dogs.
两只突然出现神经症状提示严重颈脊髓损伤的犬，尸检发现患有继发于髓核栓塞的坏死性脊髓病。一只犬的动脉和静脉均发生了栓塞；另一只犬仅静脉发生了栓塞。每只犬均有C6-7椎间盘的早期退变和突出，栓子即来源于此。在一只犬中，动脉栓子显然进入了纤维环的炎性血管，随后因椎间盘突出被挤回动脉系统，再至根动脉，进而到达脊髓。静脉栓塞继发于动脉栓塞。在另一只犬中，静脉栓塞是由于髓核直接疝入纵行静脉窦所致。对每例栓塞发病机制的比较以及对其他报道病例的调查表明，坏死性脊髓病是大型犬椎间盘早期退变的一种并发症。
