Rutishauser S C
Q J Exp Physiol Cogn Med Sci. 1980 Jan;65(1):37-46. doi: 10.1113/expphysiol.1980.sp002490.
The choleretic effects of infusions of sodium cholate, with and without the simultaneous infusion of taurine was compared with the choleretic effect of infusions of sodium taurocholate at rates ranging from 20--70 nmole/min. g. liver in anaesthetized guinea-pigs. Sodium cholate was secreted in bile mainly conjugated with taurine and with glycine. 10% was secreted unconjugated. Not more than 10% of the total bile salts secreted may have undergone reduction at C-3. The increase in bile flow with sodium cholate was generally greater than that with sodium taurocholate. The additional flow could not be correlated with the presence of glycocholate or free cholate in bile, and may be due to an action of cholate on biliary secretory mechanisms before the bile salt is secreted into the canaliculi.
在麻醉的豚鼠中，比较了以20 - 70纳摩尔/分钟·克肝脏的速率输注胆酸钠（同时输注或不输注牛磺酸）的利胆作用与输注牛磺胆酸钠的利胆作用。胆酸钠在胆汁中主要与牛磺酸和甘氨酸结合分泌。10%以未结合形式分泌。分泌的总胆汁盐中不超过10%可能在C-3位发生了还原。胆酸钠引起的胆汁流量增加通常大于牛磺胆酸钠引起的增加。额外的胆汁流量与胆汁中甘氨胆酸盐或游离胆酸盐的存在无关，可能是由于胆酸盐在胆汁盐分泌到胆小管之前对胆汁分泌机制的作用。
