Wilkinson H A, Kornblith P, Weems S
J Neurol Neurosurg Psychiatry. 1977 Apr;40(4):389-94. doi: 10.1136/jnnp.40.4.389.
Semipermeable silastic rubber membranes can be used to diffuse focally a variety of chemicals including antitumour drugs. Of the eight drugs tested, in vitro tests showed the best diffusion with dactinomycin, mithramycin, and oncovin, and the poorest diffusion with bleomycin, fluorouracil, and thiotepa. Biological testing was performed with mithramycin, dactinomycin, and oncovin using tissue cultures of human glioblastoma and subcutaneous implants of mouse ependymoblastoma. All three drugs caused rapid tissue culture cell death with direct injection, and impeded tumour growth when given intraperitoneally. Dactinomycin by silastic diffusion proved more effective than mithramycin against tissue cultures, but neither drug had a significant effect against local tumours treated with implanted drug capsules. Silastic diffusion of oncovin reduced tumour sizes significantly ipsilateral to the implant, compared to contralateral implants and to untreated controls.
半透性硅橡胶膜可用于局部扩散多种化学物质，包括抗肿瘤药物。在所测试的8种药物中，体外试验表明放线菌素、光辉霉素和长春新碱的扩散效果最佳，而博来霉素、氟尿嘧啶和噻替派的扩散效果最差。使用人胶质母细胞瘤的组织培养物和小鼠室管膜母细胞瘤的皮下植入物，对光辉霉素、放线菌素和长春新碱进行了生物学测试。直接注射时，这三种药物均导致组织培养细胞迅速死亡，腹腔注射时则抑制肿瘤生长。通过硅橡胶扩散的放线菌素在组织培养方面比光辉霉素更有效，但两种药物对植入药物胶囊治疗的局部肿瘤均无显著效果。与对侧植入物和未治疗的对照组相比，通过硅橡胶扩散的长春新碱可使植入物同侧的肿瘤大小显著减小。
