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与苯妥英钠相关的软组织假淋巴瘤反应。

A pseudolymphomatous reaction in soft tissue associated with phenytoin sodium.

作者信息

Wilden J N, Scott C A

出版信息

J Clin Pathol. 1978 Aug;31(8):761-4. doi: 10.1136/jcp.31.8.761.

DOI:10.1136/jcp.31.8.761
PMID:690240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1145403/
Abstract

A pseudolymphomatous reaction involving subcutaneous tissue and underlying skeletal muscle is described in a woman who was receiving phenytoin sodium and phenobarbitone. The histological appearance was of nodular, densely cellular tissue composed of histiocytes, plasma cells, lymphocytes, fibroblasts, and occasional polymorphonuclear cells. The significance of this finding is briefly considered in relation to the existing literature.

摘要

一名正在接受苯妥英钠和苯巴比妥治疗的女性患者出现了累及皮下组织和深层骨骼肌的假性淋巴瘤反应。组织学表现为结节状、细胞密集的组织，由组织细胞、浆细胞、淋巴细胞、成纤维细胞和偶尔的多形核细胞组成。结合现有文献简要探讨了这一发现的意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fca/1145403/f933a4e0dbf5/jclinpath00444-0059-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fca/1145403/97016bbfa10f/jclinpath00444-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fca/1145403/4d10db22b175/jclinpath00444-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fca/1145403/f933a4e0dbf5/jclinpath00444-0059-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fca/1145403/97016bbfa10f/jclinpath00444-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fca/1145403/4d10db22b175/jclinpath00444-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fca/1145403/f933a4e0dbf5/jclinpath00444-0059-b.jpg

相似文献

1
A pseudolymphomatous reaction in soft tissue associated with phenytoin sodium.与苯妥英钠相关的软组织假淋巴瘤反应。
J Clin Pathol. 1978 Aug;31(8):761-4. doi: 10.1136/jcp.31.8.761.
2
Letter: Immunoblactic lymphadenopathy associated with phenytoin (diphenylhydantoin).信函：与苯妥英钠（二苯乙内酰脲）相关的免疫母细胞性淋巴结病。
Lancet. 1976 Jan 24;1(7952):198. doi: 10.1016/s0140-6736(76)91307-6.
3
Phenytoin-induced pseudolymphoma syndrome: an immunologic study.苯妥英钠所致假性淋巴瘤综合征：一项免疫学研究。
Arch Dermatol. 1977 Apr;113(4):477-80.
4
Skeletal muscle involvement by lymphoma.淋巴瘤累及骨骼肌。
Arch Intern Med. 1986 Jun;146(6):1232.
5
Phenytoin-induced pseudolymphoma with mycosis fungoides manifestations.苯妥英钠诱导的具有蕈样肉芽肿表现的假性淋巴瘤。
Clin Pharm. 1988 Feb;7(2):153-7.
6
Soft-tissue sarcoma, malignant lymphoma, and exposure to phenoxyacids or chlorophenols.软组织肉瘤、恶性淋巴瘤以及接触苯氧酸或氯酚。
Lancet. 1982 Jun 19;1(8286):1408-9. doi: 10.1016/s0140-6736(82)92518-1.
7
Primary lymphoma arising in skeletal muscle.原发性骨骼肌淋巴瘤。
Eur J Surg Oncol. 1990 Feb;16(1):70-3.
8
Localized cutaneous pseudolymphoma associated with phenytoin therapy: a case report.与苯妥英治疗相关的局限性皮肤假性淋巴瘤：一例报告
Australas J Dermatol. 1981 Apr;22(1):28-9. doi: 10.1111/j.1440-0960.1981.tb00775.x.
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[A case of primary B-cell origin lymphoma of the stomach seen during diphenylhydantoin therapy (author's transl)].苯妥英治疗期间所见的原发性胃B细胞起源淋巴瘤1例（作者译）
Nihon Shokakibyo Gakkai Zasshi. 1981 Sep;78(9):1797-802.
10
[Case of "exanthematous pseudolymphoma" due to diphenylhydantoin hypersensitivity with a transitory immunologic deficit].[因苯妥英钠超敏反应伴短暂免疫缺陷导致的“疹性假性淋巴瘤”病例]
Clin Ter. 1980 Jul 31;94(2):229-37.

引用本文的文献

1
Anticonvulsant hypersensitivity syndrome: incidence, prevention and management.抗惊厥药物超敏反应综合征：发病率、预防与管理
Drug Saf. 1999 Dec;21(6):489-501. doi: 10.2165/00002018-199921060-00005.
2
Immunological adverse effects of anticonvulsants. What is their clinical relevance?抗惊厥药的免疫不良反应。它们的临床相关性是什么？
Drug Saf. 1993 Mar;8(3):235-50. doi: 10.2165/00002018-199308030-00005.

本文引用的文献

1
Lymphoid polyps (benign lymphoma) and malignant lymphoma of the rectum and anus.直肠和肛门的淋巴样息肉（良性淋巴瘤）及恶性淋巴瘤。
Surg Gynecol Obstet. 1951 Feb;92(2):233-43.
2
Benign lymphoid masses of probable hamartomatous nature. Analysis of 12 cases.可能为错构瘤性质的良性淋巴样肿块。12例分析。
Cancer. 1962 Jan-Feb;15:197-214. doi: 10.1002/1097-0142(196201/02)15:1<197::aid-cncr2820150128>3.0.co;2-6.
3
MESANTOIN LYMPHADENOPATHY MORPHOLOGICALLY SIMULATING HODGKIN'S DISEASE.美索因致淋巴结病，形态学上酷似霍奇金病。
Ann Intern Med. 1963 Sep;59:363-8. doi: 10.7326/0003-4819-59-3-363.
4
PULMONARY MALIGNANT LYMPHOMAS AND PSEUDOLYMPHOMAS: CLASSIFICATION, THERAPY, AND PROGNOSIS.肺恶性淋巴瘤与假性淋巴瘤：分类、治疗及预后
Cancer. 1963 Jul;16:928-55. doi: 10.1002/1097-0142(196307)16:7<928::aid-cncr2820160709>3.0.co;2-h.
5
Generalized lymphadenopathy and hepatosplenomegaly induced by diphenylhydantoin.苯妥英钠引起的全身性淋巴结病和肝脾肿大。
Pediatrics. 1961 Dec;28:943-5.
6
Syndrome simulatingqymphosarcoma induced by diphenylhydantoin sodium.由苯妥英钠诱发的类似淋巴肉瘤综合征。
JAMA. 1961 May 13;176:491-3. doi: 10.1001/jama.1961.03040190013004.
7
Lymphadenopathy induced by anticonvulsant drugs and mimicking clinically pathologically malignant lymphomas.抗惊厥药物所致淋巴结病，临床病理表现酷似恶性淋巴瘤。
Cancer. 1959 Jan-Feb;12(1):164-82. doi: 10.1002/1097-0142(195901/02)12:1<164::aid-cncr2820120122>3.0.co;2-y.
8
Malignant lymphoma associated with hydantoin drugs.
Arch Neurol. 1970 May;22(5):450-4. doi: 10.1001/archneur.1970.00480230068008.
9
Hydantoin-induced pseudo-pseudolymphoma.乙内酰脲诱导的假性假性淋巴瘤。
Ann Intern Med. 1968 Sep;69(3):557-68. doi: 10.7326/0003-4819-69-3-557.
10
The development of Hodgkin's disease and lymphoma during anticonvulsant therapy.抗惊厥治疗期间霍奇金病和淋巴瘤的发生
Blood. 1966 Sep;28(3):416-27.