Larsen J A, Thomsen O O
Basic Res Cardiol. 1980 May-Jun;75(3):428-32. doi: 10.1007/BF01908406.
The present experiments demonstrate that vanadate (sodium orthovanadate) given i.v. to anesthetized cats induces a marked, transient and reversible constriction of visceral arteries, including the renal artery, whereas the femoral and carotid artery escape constriction. The constriction of the renal artery is accompanied by a pronounced reduction of glomerular filtration rate and urine production. The vasoconstriction appears to be caused by a direct effect of vanadate on the vessel wall, but the mechanism of action is not established.
目前的实验表明，静脉注射钒酸盐（正钒酸钠）给麻醉的猫会引起包括肾动脉在内的内脏动脉显著、短暂且可逆的收缩，而股动脉和颈动脉则不会收缩。肾动脉收缩伴随着肾小球滤过率和尿量的显著降低。血管收缩似乎是由钒酸盐对血管壁的直接作用引起的，但作用机制尚未明确。
