High-performance liquid chromatographic assay of sulfapyridine and acetylsulfapyridine in biological fluids.
作者信息
Owerbach J, Johnson N F, Bates T R, Pieniaszek H J, Jusko W J
出版信息
J Pharm Sci. 1978 Sep;67(9):1250-3. doi: 10.1002/jps.2600670916.
PMID:690830
Abstract
A high-pressure liquid chromatographic method for the sensitive, rapid, and specific determination of sulfapyridine and its N-acetyl derivative in plasma and saliva was developed. A cyano-bonded, reversed-phase, high efficiency column was used. The system detected these sulfonamides in serum to 0.25 mg/liter and within only 6 min. Sulfapyridine was separated from its acetyl derivative with little interference from other drugs. The assay reproducibility was within 3%. The assay was highly useful for routine monitoring of patients receiving sulfasalazine for inflammatory bowel disease.
摘要
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