Haddad R, Grabner G, Strasser G, Braun F
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;216(3):219-25. doi: 10.1007/BF00408163.
The possible roles of prostaglandins and a neural pathway in the disruption of the blood-aqueous barrier in the rabbit eye after cyclocryocoagulation were studied. Both the preoperative IV administration of the prostaglandin inhibitor acetylsalicylic acid and the application of retrobulbar and topical anesthesia reduced IOP and decreased breakdown of the blood-aqueous barrier, as measured by protein in the aqueous humour. These results imply that the acute response of the animal eye to cyclocryocoagulation is mediated partly by prostaglandins and partly by a neural component resistent an inhibitor of prostaglandin synthesis. When administered together, acetylsalicylic acid and ocular anesthesia yielded a further reduction in postoperative reactions and protein concentrations in the aqueous humour, but were unable to abolish the ocular response completely. The dual ocular mediation to cyclocryocoagulation is apparently due to the combined thermal and mechanical injury caused to ocular structures which synthesize prostaglandins and receive sensory innervation from the trigeminal nerve. The considerable breakdown of the blood-aqueous barrier in cyclocryocoagulation allows leakage of different molecular weight proteins, in equal ratio, into the aqueous humour.
研究了前列腺素和神经通路在兔眼睫状体冷凝术后血-房水屏障破坏中的可能作用。术前静脉注射前列腺素抑制剂乙酰水杨酸以及球后和局部麻醉的应用均降低了眼压，并减少了血-房水屏障的破坏，这通过房水中的蛋白质来衡量。这些结果表明，动物眼对睫状体冷凝的急性反应部分由前列腺素介导，部分由对前列腺素合成抑制剂有抗性的神经成分介导。当乙酰水杨酸和眼部麻醉联合使用时，术后反应和房水中的蛋白质浓度进一步降低，但无法完全消除眼部反应。对睫状体冷凝的双重眼部介导显然是由于对合成前列腺素并接受三叉神经感觉神经支配的眼部结构造成的热和机械损伤共同作用的结果。睫状体冷凝术中血-房水屏障的显著破坏使得不同分子量的蛋白质以相等的比例漏入房水。
