Current approaches to development of the autonomic nervous system: clues to clinical problems.

A number of different approaches to autonomic development utilizing a variety of experimental models and analytical techniques have been outlined. A scheme, which attempts to delineate a series of events involving separate but sometimes overlapping mechanisms, is proposed for the complex process of formation and maintenance of functional autonomic neuroeffector junctions. The relevance of these basic mechanisms of a variety of clinical abnormalities of autonomic function is discussed.