Ponnath H, Weitzel H, Benthin D
Geburtshilfe Frauenheilkd. 1981 Dec;41(12):849-52. doi: 10.1055/s-2008-1037303.
Sulproston was used to terminate 125 pregnancies from 13 to 41 weeks duration, between 1.1.1979 and 31.12.1980. The indications for termination of pregnancy included medical problems, genetic disorders and neural tube defects. Sulproston alone was used in 30 cases. In the remaining 95 cases the cervix uteri was treated with Minprostin F2a before Sulproston application. The failure rate was 20% when Sulproston alone was used at varying dosage. There were no failures using the combination therapy. Combined therapy reduced the time necessary for abortion by an average of four hours, the period of painful contractions was reduced, and less Sulproston was needed. The incidence of side effects was comparable in the two groups. There were no complications from the intracervical application of Minprostin F2a.
1979年1月1日至1980年12月31日期间，使用舒前列素终止了125例怀孕，孕期为13至41周。终止妊娠的指征包括医学问题、遗传性疾病和神经管缺陷。30例单独使用舒前列素。其余95例在使用舒前列素前先用卡前列甲酯治疗子宫颈。单独使用舒前列素时，不同剂量的失败率为20%。联合治疗无失败病例。联合治疗平均减少了流产所需时间4小时，缩短了疼痛宫缩期，且所需舒前列素更少。两组副作用发生率相当。卡前列甲酯宫颈内给药无并发症。
