Semba T, Mizonishi T
Jpn J Physiol. 1978;28(2):239-48. doi: 10.2170/jjphysiol.28.239.
The atropine-resistant contraction of the alimentary canal, first reported by CAMPBELL (1966) and subsequently confirmed by others, was examined in dog in vivo. The gastric and colonic motor excitations were examined by stimulating the extrinsic nerves, the medulla oblongata or the spinal cord and its roots. Prolonged stimulation of the vagus, medulla oblongata or splanchnic nerve, thoracic cord and its dorsal root produced excitation of the gastric motility even after intravenous injection of sufficient atropine, although the intensity and frequency of peristalsis were slightly reduced. Prolonged latent periods were characteristic of the atropine-resistant excitation in the stomach, the latency being 29.8--49.4 sec as compared to 2.3--14.5 sec in control (without atropine). On the other hand, the colonic excitation induced by the stimulation of the pelvic nerve, or sacral cord and its ventral root was not inhibited by atropine; no prolongation in latency and reduction of peristalsis was observed.
坎贝尔（1966年）首次报道、后经其他人证实的消化道对阿托品耐药性收缩，在活体狗身上进行了研究。通过刺激外周神经、延髓或脊髓及其神经根来检测胃和结肠的运动兴奋。即使静脉注射足量阿托品后，长时间刺激迷走神经、延髓或内脏神经、胸段脊髓及其背根，仍会引起胃蠕动兴奋，尽管蠕动的强度和频率略有降低。胃中对阿托品耐药性兴奋的特征是潜伏期延长，潜伏期为29.8 - 49.4秒，而对照组（未用阿托品）为2.3 - 14.5秒。另一方面，刺激盆神经、骶段脊髓及其腹根所诱发的结肠兴奋不受阿托品抑制；未观察到潜伏期延长和蠕动减弱。
