Henk J M, Kunkler P B, Smith C W
Lancet. 1977 Jul 16;2(8029):101-3. doi: 10.1016/s0140-6736(77)90116-7.
We report the results of a prospective controlled trial of the effect of hyperbaric oxygen as an adjuvant in radiotherapy of head and neck cancer. Patients were allocated randomly to treatment in oxygen or air. The radiotherapy in both groups was identical in planning, dose, and fractionation--i.e., 3500 rads in 10 fractions in 3 weeks. There was no difference in the survival rate between the two groups. However, significantly better local tumour control was seen in the hyperbaric-oxygen group, particularly in smaller lesions; there was significantly greater need for salvage surgery in the air group. Radiation effects on normal tissue appeared somewhat greater in the oxygen series, especially on laryngeal cartilage.
我们报告了一项前瞻性对照试验的结果，该试验旨在研究高压氧作为头颈癌放射治疗辅助手段的效果。患者被随机分配到在氧气环境或空气环境中接受治疗。两组的放射治疗在计划、剂量和分割方式上均相同，即3周内分10次给予3500拉德的剂量。两组的生存率没有差异。然而，高压氧组的局部肿瘤控制明显更好，尤其是在较小的病变中；空气组进行挽救性手术的需求明显更大。在氧气组中，对正常组织的放射效应似乎更大，尤其是对喉软骨的影响。
