Jouve R, Puddu P E, Torresani J
Heart Lung. 1982 Sep-Oct;11(5):399-405.
The electrical systole duration (QTc), heart rate, and the QTc/QTt ratio were studied during the hospital course of an uncomplicated AMI in 13 patients treated with bretylium tosylate (10 mg/mg/24 hr over 5 days since confirmation of AMI) and in 19 controls. The QTc/QTt ratio showed prolongation of electrical systole duration in control subjects with a maximal value at the second day after AMI. QTc increased in these patients from day 1 to day 2 after AMI (402 +/- 4 msec vs. 430 +/- 3 msec, p less than 0.05) and decreased in the following days (p less than 0.05). During hospitalization cardiac rate was constant in both groups. In contrast, patients treated with bretylium tosylate showed a stable duration of QTc and the QTc/QTt ratio did not indicate prolongation of electrical systole duration. After drug discontinuation a slight increase in QTc duration was noticed (391 +/- 6 msec vs. 413 +/- 5 msec, p less than 0.05). These observations may contribute to the understanding of the antiarrhythmic action of bretylium and would indicate its usefullness in AMI patients with prolonged QTc and high risk of life-threatening arrhythmias.
对13例急性心肌梗死（AMI）病情不复杂且接受溴苄铵治疗（自确诊AMI起5天内，剂量为10mg/kg/24小时）的患者以及19例对照者在住院期间的电收缩期时长（QTc）、心率和QTc/QTt比值进行了研究。QTc/QTt比值显示，对照者的电收缩期时长延长，在AMI后第二天达到最大值。这些患者的QTc在AMI后第1天到第2天增加（402±4毫秒对430±3毫秒，p<0.05），在随后几天下降（p<0.05）。住院期间两组的心率均保持恒定。相比之下，接受溴苄铵治疗的患者QTc时长稳定，QTc/QTt比值未显示电收缩期时长延长。停药后，QTc时长略有增加（391±6毫秒对413±5毫秒，p<0.05）。这些观察结果可能有助于理解溴苄铵的抗心律失常作用，并表明其在QTc延长且有发生危及生命心律失常高风险的AMI患者中的有用性。
