Callaghan R, Cabanes J, Pellin A, Llombart-Bosch A
Rev Esp Oncol. 1982;29(3):423-7.
The evolution of ploidy of liver cells during malignant transformation by N-nitrosomorpholine was studied cytophotometrically. It was observed an increased ploidy that was due to the toxic action of the product and lasted six weeks, and a gradual return to normal values after the administration of the drug was discontinued.
用细胞光度法研究了N-亚硝基吗啉诱导肝细胞恶性转化过程中细胞倍性的演变。观察到由于该产物的毒性作用,细胞倍性增加,持续六周,停药后逐渐恢复到正常值。