Agner E, Thorsteinsson B, Eriksen M
Diabetes Care. 1982 Nov-Dec;5(6):600-4. doi: 10.2337/diacare.5.6.600.
In a 10-yr prospective population study 406 subjects who were 70 yr old received an oral glucose tolerance test. Of these subjects 169 were retested at 80. Three sets of diagnostic criteria were evaluated, of which the WHO criteria are recommended for screening studies in this age group. The prevalences of diabetes mellitus (DM) and impaired glucose tolerance (IGT) according to the latter criteria were 10% and 26% at 70 and 12% and 35% at 80 in men and women. Excess 10-yr mortality was seen in both sexes when DM existed at 70, and in men also when IGT existed at this age. The excess mortality in men could solely--and in women partly--be explained by cardiovascular diseases. The 10-yr incidence of DM was 20% if IGT existed at 70, but only 4% when normal glucose tolerance was present at 70.
在一项为期10年的前瞻性人群研究中，406名70岁的受试者接受了口服葡萄糖耐量试验。其中169人在80岁时再次接受测试。评估了三组诊断标准，其中世界卫生组织（WHO）标准推荐用于该年龄组的筛查研究。根据后一种标准，男性和女性在70岁时糖尿病（DM）和糖耐量受损（IGT）的患病率分别为10%和26%，在80岁时分别为12%和35%。当70岁时患有DM时，男女两性均出现10年超额死亡率，当该年龄患有IGT时，男性也出现超额死亡率。男性的超额死亡率完全可以——女性部分可以——由心血管疾病解释。如果70岁时存在IGT，DM的10年发病率为20%，但70岁时葡萄糖耐量正常时仅为4%。
