Lee F C, Walker R F, Hatcher J D
Occup Health Saf. 1977 Jul-Aug;46(4):42-5.
Cotton dust particle distribution in respiratory airways was measured to determine if specific size particles of the heterogeneous dust are concentrated as a function of airway diameter. Previously reported work indicated that the fine particles are responsible for the decrement in pulmonary function which occurs subsequent to cotton dust inhalation. After recovery, particles were sized and counted microscopically. Significant increases in fine particles (5-7 mu) were found in all airways of exposed animals as compared with controls. These particles become more concentrated as the airway diameter decreased. Histamine determinations were made in mice lungs after the animals were exposed to cotton dust for various periods of time to see if such treatment could be correlated with elevations in the concentrations of this biogenic amine. Lung histamine increased as exposure time to cotton dust increased. It is concluded that the lung histamine release occurring after cotton dust inhalation is related to some property of the fine particles of the heterogeneous dust.
测量呼吸道中棉尘颗粒的分布，以确定这种异质粉尘的特定尺寸颗粒是否会随着气道直径的变化而集中。先前报道的研究表明，细颗粒是吸入棉尘后肺功能下降的原因。恢复后，通过显微镜对颗粒进行大小测量和计数。与对照组相比，暴露动物的所有气道中细颗粒（5-7微米）显著增加。随着气道直径减小，这些颗粒变得更加集中。在动物暴露于棉尘不同时间段后，对小鼠肺部进行组胺测定，以观察这种处理是否与这种生物胺浓度的升高相关。随着暴露于棉尘的时间增加，肺组胺含量升高。得出的结论是，吸入棉尘后发生的肺组胺释放与异质粉尘细颗粒的某些特性有关。
