Schweinle J E, Alperin J B
Cancer. 1980 Jan 1;45(1):16-8. doi: 10.1002/1097-0142(19800101)45:1<16::aid-cncr2820450105>3.0.co;2-x.
Therapy with vincristine and prednisone achieved a complete remission in a 10-year-old Caucasian girl with acute lymphoblastic leukemia. Maintenance therapy with 6-mercaptopurine was then administered for seven years, but prophylactic intrathecal chemotherapy and central nervous system (CNS) radiation were never given the patient. Ten years from the time of diagnosis, she presented with signs of increased intracranial pressure and a diagnosis of CNS leukemia was confirmed. At this time, however, no leukemia was detected on examination of her blood and bone marrow. She was successfully treated with intrathecal methotrexate and radiation therapy. After a careful search of the literature it has been concluded that this is the first reported case of such a long remission of acute lymphoblastic leukemia with subsequent relapse.
长春新碱和泼尼松治疗使一名患有急性淋巴细胞白血病的10岁白种女孩完全缓解。随后给予6-巯基嘌呤维持治疗7年，但从未对该患者进行预防性鞘内化疗和中枢神经系统（CNS）放疗。自诊断之时起10年后，她出现颅内压升高的症状，CNS白血病的诊断得到证实。然而，此时在她的血液和骨髓检查中未检测到白血病。她接受鞘内甲氨蝶呤和放疗后获得成功治疗。在对文献进行仔细检索后得出结论，这是首例报道的急性淋巴细胞白血病如此长时间缓解后复发的病例。
