Knazek R A, Liu S C, Bodwin J S, Vonderhaar B K
J Natl Cancer Inst. 1980 Feb;64(2):377-82. doi: 10.1093/jnci/64.2.377.
The ductal system of mammary glands in C3H mice that were started on diets deficient in essential fatty acid(s) (EFA) 1--2 weeks after weaning developed at a normal rate. The alveolar structures, however, began to disappear in the mice after 17 weeks on the EFA-deficient regimen. Injection sc of linoleic acid prevented the atrophic process. Alveoli were also absent in the glands of multiparous mice that were maintained for 32 weeks on the EFA-deficient diet. When the EFA-deficient regimen was started in females during midpregnancy and maintained continuously thereafter, both ductal and alveolar structures failed to develop in the mammary glands of the offspring. Linoleic acid appears to be required for development of ductal and alveolar structures during growth of the mammary gland and also for maintenance of the alveolar structures in the adult mammary gland.
在断奶后1 - 2周开始食用缺乏必需脂肪酸（EFA）日粮的C3H小鼠中，乳腺导管系统以正常速率发育。然而，在缺乏EFA的饲养方案下饲养17周后，小鼠的腺泡结构开始消失。皮下注射亚油酸可防止萎缩过程。在缺乏EFA的日粮中饲养32周的经产小鼠的腺体中也没有腺泡。当在妊娠中期开始对雌性小鼠采用缺乏EFA的饲养方案并持续维持时，后代的乳腺中导管和腺泡结构均未能发育。亚油酸似乎是乳腺生长过程中导管和腺泡结构发育以及成年乳腺中腺泡结构维持所必需的。
