Schwenk H U, Seiler G, Engelhardt K, Kühner U
Klin Padiatr. 1980 Jan;192(1):39-44. doi: 10.1055/s-2008-1033857.
It is concluded from the prognostic factors of acute lymphoblastic leukaemia, as far as they have become known up to now, such as initial leukocyte count, extent of organ infiltration, etc, that the pre-diagnostic duration of signs, representing a measure of the proliferation activity of the leukaemia cells, could also represent a relevant prognostic characteristic. A check conducted in 90 children treated between 1966--1975 yields a correlation only between a very short pre-diagnostic duration of signs (less than 2 weeks) and the duration of the first complete remission (as well as the survival time). However, even those prognostic factors which are already generally recognised, possess merely limited reliability, because they do not take the individual response to therapy into account. Hence, improvement of prognosis of the course of the disease can be expected only if the continuous decrease of the remaining population of blasts during the early phase of remission can be determined with greater accuracy than before.
从急性淋巴细胞白血病的预后因素来看，就目前所知，如初始白细胞计数、器官浸润程度等，症状出现前的持续时间作为白血病细胞增殖活性的一种度量，也可能是一个相关的预后特征。对1966年至1975年间接受治疗的90名儿童进行的一项检查发现，只有症状出现前持续时间非常短（少于2周）与首次完全缓解的持续时间（以及生存时间）之间存在相关性。然而，即使是那些已被普遍认可的预后因素，其可靠性也仅有限，因为它们没有考虑个体对治疗的反应。因此，只有在缓解早期能够比以前更准确地确定残留原始细胞群体的持续减少情况时，才有望改善疾病进程的预后。
