阿糖胞苷诱导的过敏反应。抗体的证实及成功脱敏

Cytarabine-induced anaphylaxis. Demonstration of antibody and successful desensitization.

作者信息

Rassiga A L, Schwartz H J, Forman W B, Crum E D

出版信息

Arch Intern Med. 1980 Mar;140(3):425-6. doi: 10.1001/archinte.140.3.425.

DOI:10.1001/archinte.140.3.425

Abstract

An anaphylactic episode occurred in a patient receiving cytarabine (Ara-C) for acute myeloid leukemia. Specific allergy of the patient to cytarabine was demonstrated in vivo by intradermal testing and in vitro by four-hour passive cutaneous anaphylaxis in guinea pigs. Desensitization to cytarabine was successfully performed. This case represents the first known report of both cytarabine anaphylaxis and densensitization, and provides immunologic evidence implicating an allergic reaction to cytarabine.

摘要

一名接受阿糖胞苷（Ara-C）治疗急性髓系白血病的患者发生了过敏反应。通过皮内试验在体内以及通过豚鼠四小时被动皮肤过敏反应在体外证实了该患者对阿糖胞苷的特异性过敏。成功实施了对阿糖胞苷的脱敏治疗。该病例代表了阿糖胞苷过敏反应和脱敏治疗的首例已知报告，并提供了涉及对阿糖胞苷过敏反应的免疫学证据。