Grossman M E, Silvers D N, Walther R R
J Am Acad Dermatol. 1980 Feb;2(2):111-6. doi: 10.1016/s0190-9622(80)80388-4.
Recognition of the characteristic cutaneous lesions of disseminated candidiasis may allow earlier diagnosis and treatment of this often fatal fungal infection. The skin lesion developed in patients with hematologic malignancies and compromised host defenses, at a time when they were febrile, clinically deteriorating, and failing to respond to multiple antibiotics. This report discusses two patients with acute myelogenous leukemia with cutaneous manifestations of disseminated candidiasis due to Candida tropicalis. Single or multiple erythematous or purpuric 0.5- to 1-cm papulonodules with pale centers were seen on the trunk and proximal extremities. In most reported cases of disseminated candidiasis with skin lesions, the diagnosis can be confirmed by histologic evaluation of a skin biopsy before appropriate cultures identify the organism.
认识播散性念珠菌病的特征性皮肤损害可能有助于对这种往往致命的真菌感染进行早期诊断和治疗。皮肤损害出现在血液系统恶性肿瘤患者以及宿主防御功能受损的患者身上，此时他们发热、临床状况恶化且对多种抗生素无反应。本报告讨论了两名患有急性髓性白血病且有热带念珠菌所致播散性念珠菌病皮肤表现的患者。在躯干和近端肢体可见单个或多个中心苍白的0.5至1厘米红斑或紫癜性丘疹结节。在大多数有皮肤损害的播散性念珠菌病报告病例中，在适当培养鉴定出病原体之前，可通过皮肤活检的组织学评估来确诊。
