Valeriote F, Vietti T, Coulter D
J Natl Cancer Inst. 1980 Apr;64(4):801-5.
The combination of adriamycin and methotrexate was found in mice to be synergistic in cytotoxicity to L1210 leukemia cells for a range of time intervals between the two agents. Cytotoxicity for normal hematopoietic stem cells was less than additive. Spleen colony assays were used to quantitate both cell populations. Increase in life-span assays yielded similar results. Also, the extent of synergy was dependent on the dose of adriamycin only.
在小鼠实验中发现，阿霉素与甲氨蝶呤联合使用时，在两种药物之间的一系列时间间隔内，对L1210白血病细胞具有细胞毒性协同作用。对正常造血干细胞的细胞毒性小于相加作用。脾集落试验用于定量这两种细胞群体。生存期延长试验得出了类似的结果。此外，协同程度仅取决于阿霉素的剂量。
