Abdelfattah-Gad M, Denk H
J Natl Cancer Inst. 1980 May;64(5):1025-8.
Blood group antigen content of human carcinomas located in the distal large bowel (descending colon, sigmoid colon, and rectum) was determined by the specific red cell adherence reaction and was compared to several morphologic features of prognostic significance, e.g., differentiation, extent of tumor spread, peritumoral lymphoplasmocytic infiltration, and growth patterns. About 50% of the carcinomas expressed blood group antigens in either diffuse or patchy distribution. Classification of tumors according to the extent of local spread revealed that 60% of Dukes stage A tumors were blood group antigen-negative, whereas 58% of those in Dukes stage B were positive. Dukes stage C lesions had an intermediate position, and this limits the prognostic usefulness of blood group antigen determinations. No significant correlations were found between blood group antigenicity and the degree of histologic differentiation, the degree of peritumoral lymphoplasmocytic infiltration, and the mode of tumor growth.
通过特异性红细胞黏附反应测定位于大肠远端（降结肠、乙状结肠和直肠）的人类癌组织的血型抗原含量，并将其与一些具有预后意义的形态学特征进行比较，例如分化程度、肿瘤扩散范围、肿瘤周围淋巴浆细胞浸润以及生长模式。约50%的癌组织以弥漫或斑片状分布表达血型抗原。根据局部扩散程度对肿瘤进行分类显示，60%的杜克A期肿瘤血型抗原呈阴性，而杜克B期肿瘤中58%呈阳性。杜克C期病变处于中间位置，这限制了血型抗原测定在预后方面的实用性。未发现血型抗原性与组织学分化程度、肿瘤周围淋巴浆细胞浸润程度以及肿瘤生长方式之间存在显著相关性。
