Motta G, Spinelli E, Tagnin R, Agati R, Ratto G B, Nahum M
Minerva Chir. 1978 Oct 15;33(19):1263-74.
Certain fluorinated carbonate compounds can carry O2 and CO2 in a physiological manner. This faculty was exploited in the elaboration of an experimental intra-alveolar oxygenating washing protocol employing such compounds as intrapulmonary oxygenating liquids conveyed by transtracheal flooding of the alveoli in 20 rabbits. AP, PaP, CVP and EP were monitored in accordance with a 35' protocol, during which the positive oxygenation and negative emptying phases of the washing process were repeated at an average 2 cycles/min. A respiratory exchange capable of keeping all the animals alive until the recommencement of spontaneous ventilation was noted, along with only slight changes in lung structure. Once an in-depth study is made of certain fundamental phenomena related to structure and lung function, it is felt that this washing method can be used clinically for the treatment of hypoxaemic situations in which normal alveocapillary exchange is impeded by extraneous material, as in desquamative interstitial pneumonia, pulmonary alveolar proteinosis, etc.
某些氟化碳酸酯化合物能够以生理方式携带氧气和二氧化碳。在一项实验性的肺泡内氧合冲洗方案中利用了这一特性，该方案使用此类化合物作为肺内氧合液，通过经气管向20只兔子的肺泡内注入液体来实施。按照一个35分钟的方案监测平均肺动脉压（AP）、肺动脉压（PaP）、中心静脉压（CVP）和呼气末正压（EP），在此期间，冲洗过程的正性氧合和负性排空阶段以平均每分钟2个周期的频率重复。观察到一种呼吸交换能够使所有动物存活至自主通气重新开始，同时肺结构仅有轻微变化。一旦对与结构和肺功能相关的某些基本现象进行深入研究，人们认为这种冲洗方法可在临床上用于治疗低氧血症情况，如在脱屑性间质性肺炎、肺泡蛋白沉积症等中，正常的肺泡毛细血管交换因外来物质而受阻。
